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KMID : 0615720140310020039
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 2 p.39 ~ p.50
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The Effect of Tokoro Rhizoma Pharmacopuncture at KI10 in Lipopolysaccharide Induced Acute Nephritis in Rats
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Kim Yun-Joo
Kang Jae-Hui
Lee Hyun
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Abstract
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Objectives : This study was designed to evaluate the effects of Tokoro Rhizoma pharmat KI10 in nephritis induced by lipopolysaccharide(LPS) in rat.
Methods : Rats were divided into 4 groups and 3 groups(LPS, saline, Tokoro Rhizoma pharmacopuncture(TR-P) group) were injected LPS to induce nephritis. TR-P group was treated with TR at KI10 three times for a week, saline group with normal saline. To evaluate the effects of TR at KI10 on nephritis in rats, white blood cell(WBC), neutrophil in blood, creatinine, cytokine-induced neutrophil chemoattractant-1(CINC-1) in serum and urinary volume, creatinine in urine, renal myeloperoxidase(MPO) were measured and renal tissue was analyzed.
Results : TR-P group significantly reduced WBC, neutrophil in blood, creatinine, CINC-1 in serum, creatinine in urine and renal MPO than LPS group. TR-P group increased urinary volume but, not significant.
Conclusion : TR at KI10 has a therapeutic effect on nephritis in LPS stimulated rat. Therefore, it is suggested that TR at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
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KEYWORD
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Tokoro Rhizoma, Nephritis, Pharmacopuncture, KI10, LPS.
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